Endocrine Abstracts

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. For the majority of patients with PTC, the prognosis is very good; however, up to 20% of patients suffer disease recurrence. Currently, the risk stratification for PTC recurrence is based on clinicopathological features which have limited prognostic value. Identification of molecular biomarkers of PTC recurrence such as protooncogene BRAF and miRNAs may help to improve risk-stratifie...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) production by the pulmonary neuroendocrine tumour (p-NET) is rare, and is considered an aggressive variant of carcinoid tumours with poor prognosis.Case presentation: 59-year-old male with fast progressing generalized fatigue, abdominal discomfort, and diarrhea was hospitalized in gastroenterology unit of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK). Digestive tra...

Introduction: ACTH producing macroadenoma and pituitary apoplexy are rare in Cushing’s disease. Somatostatin receptor agonist Pasireotide is indicated for the treatment of patients with Cushing’s disease for whom surgery is not an option or has failed. We present a case of pituitary apoplexy in patient with recurrence of Cushing’s disease treated with Pasireotide.Case: 38 years old female presented with quick weight gain, weakness, irregul...

Anaplastic thyroid carcinoma (ATC) is a rare form of thyroid carcinoma that is associated with an extremely poor prognosis. Ultrasonography (US) and subsequent fine needle aspiration biopsy (FNAB) are the first diagnostic methods in the assessment of a palpable thyroid mass. Nevertheless, some clinical and US features of ATC are not specific. Here, we report on an extremely rare case of ATC masquerading as subacute thyroiditis (SAT).A 40-year-old woman w...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. 20 – year survival rate is about 90%. However, PTC can be aggressive – up to 30% of the patients have local renewal or systemic spread.Our objective was to evaluated the clinicopathological factors of recurrence in completely resected PTC patients.Methods: A r...

Introduction: Fine-needle aspiration (FNA) is the most accurate diagnostic approach for determining thyroid nodule malignancy. Most nodules are benign, therefore, only suspicious ones require FNA. In 2017 American College of Radiology proposed a scoring system – Thyroid Imaging, Reporting and Data System (TI-RADS) for identifying clinically significant malignancies. Whether a nodule requires FNA depends on various criteria, one of which is the size. The aim of this study ...

Introduction: Despite low mortality rates of patients with papillary thyroid carcinoma (PTC), disease progression in PTC occurs in up to 20% of patients. Currently, recurrence risk stratification is accomplished by using clinicopathologic factors, despite their limited prognostic value. Some data suggest that patient age at disease onset and primary tumor size may predict the risk of disease progression. Identification of possible associations of traditional clinicopathologica...

Background: World Health Organization (WHO), United Nations International Children’s Emergency Fund (UNICEF), and the International Council for Control of Iodine Deficiency Disorders included neonatal thyroid stimulating hormone (nTSH) as one of the indicators for assessing iodine deficiency at a population level and as a monitoring tool in programs of iodine supplementation. A prevalence of nTSH concentrations in dry blood spots (DBS) above 5 mlU/l below 3% has been prop...

Background: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation and intellectual disability. The overall incidence of CH ranges from 1 in 3,000 to 1 in 4,000 live births, with variation worldwide among different ethnicity [1]. During the period 1993–2000 the incidence of CH in Lithuanian population was estimated as 1 in 4800 live births [2]. The aim of present study was to determine the incidence of CH among new-borns in Lithu...

Iodine deficiency is the main cause of preventable mental retardation in children. Urinary iodine excretion is a marker of recent iodine intake and is used to monitor the iodine status of population. Iodine excretion in Lithuanian schoolchildren was previously investigated in 2001. The main objective of this study was to evaluate iodine excretion in children, ages 6–12, living in Vilnius, Lithuania.MethodsUrine samples were co...